Inflammatory and endothelial dysfunction markers in females with metabolic syndrome aged 50–75 years

Introduction: The prevalence of metabolic syndrome (MetS) in Indonesia is 39% and it higher females than males (46% vs. 28%). Features this comprise low-grade chronic inflammation endothelial dysfunction from cardiometabolic abnormalities. High-sensitive C-reactive protein (HsCRP) a biomarker cardiovascular disease, whereas ferritin pentraxin-3 (PTX-3) are markers inflammation. One the an intercellular cell adhesion molecule-1 (ICAM-1). Studies on MetS women aged 50–70 years using several rare. study aimed to determine differences HsCRP, ferritin, PTX-3, ICAM-1 level between with without 50–75 years. Methods: For cross-sectional study, 160 South Jakarta were recruited, divided into non-MetS (control) groups, 80 participants each. Participants that met inclusion criteria assessed for vital signs parameters (e.g., lipid profile, fasting blood glucose level, waist circumference [WC]). groups compared independent t-test inflammatory (i.e., ferritin) (ICAM-1) (p < 0.05) biomarkers. Results: mean age control was 59.6 ± 5.6 59.2 5.5 included WC ≥80 cm (95.2%), increased pressure (90.6%); high-density lipoprotein cholesterol <50 mg/dL (76.2%). Significant found = 0.027), PTX-3 0.045), 0.004) but not HsCRP 0.136). Conclusion: Elevated significantly associated Mets risk years; however, same true HsCRP.